A San Francisco Pet Hotel company, Day 'n' Night Pet Hotels, is going to be moving into the space currently occupied by the McDonald's on Connecticut Avenue and Newark Street. As far as I can tell, unlike restaurants, there's no zoning against a pet hotel. (But the pet hotel will apparently have a restaurant for pets and this may be an issue -- more about that when I have more information.)
Not that a pet hotel is a bad idea. But Day 'n' Night Pet Hotels appears to be both a pet hotel and
brothel. That's pretty clear from reading their website: